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Disease-related causes:

• Diabetes - Causes nerve and artery damage which can make achieving an erection difficult.
• Kidney Disease - Causes chemical and hormonal changes which often lead to lover libido and sexual performance.
• Neurological Diseases - Damage to the normal functioning of the nerves and brain make it difficult to achieve and maintain an erection. Common examples include strokes, multiple sclerosis (MS), Alzheimer's, and Parkinson's disease.
• Vascular Disease - Account for up to 70% of all diagnosed ED causes due to restrictions in blood flow to the heart, brain, and penis.

Non-disease related causes of ED:

• Prostate or Bladder Surgery - damage or removal of nerves and tissue in the pelvic region can often cause physical desensitization in men.
• Injuries - Physical injuries to the pelvis, lower spinal column, bladder, and penis can cause long term blood flow or sensitivity problems.
• Hormonal Imbalances - Often associated with andropause in middle aged men, imbalances of the thyroid, prolactin, and testosterone can all negatively impact a man's sexual virility.
• Venous Leak - Occurs when the veins in the penis are physically unable to stop the blood from flowing back out of the penis, making an erection impossible.
• Tobacco, Alcohol, or Drug Use - These substances have been clinically proven to damage blood vessels and restrict blood flow throughout the body, ultimately leading to erectile dysfunction.
• Prescription Drugs - Over 200 types of prescription drugs are known to cause ED.
• Prostate Enlargement - Recently implicated as being associated with ED, enlarged prostates may be causing restrictions in nerve and blood vessel function.